Skip to content
Free delivery on all orders over R750
Click Here
Chat with qualified skin therapists
Click Here
Free samples with every order
Click Here
Explore free gifts & promotions
Click Here
Hello 👋
Shop by Product Type

Shop All

Ampoules
Baby
Barrier Creams
BB & CC Creams
Body
Cleansers
Day Creams
Essences
Exfoliators
Eye Care
Foot Treatments
Foundation
Gift Vouchers
Haircare
Hand & Nail
Masks
Men
Micellar Waters
Moisturisers
Neck Treatments
Night Creams
Oils
Oral Care
Serums
Starter Kits
Sunscreens
Supplements
Targeted Treatments
Toners
Tools & Devices
Shop by Brand

Shop All

Purcell
Melumé Skinscience
SkinCeuticals
Huxley
NeoStrata®
Heliocare
Beaut™
Jorgobé
MartiDerm
Lamelle
iS Clinical
Hyaestic
pHformula
Kiehl's
mesoestetic
Obagi
La Roche-Posay
ISDIN
Shop by Concern
Actinic Keratosis
Adult Acne
Atopic Eczema
Blackheads
Expression Lines
Eyelash & Eyebrow
Keratosis Pilaris
Lips
Perioral Dermatitis
Post-Acne Marks
Post-Treatment
Pregnancy
Psoriasis
Redness
Scars
Seborrhoeic Dermatitis
Stretch Marks
Shop by Science

Shop All

Retinoids
Vitamin C
Hyaluronic Acid
Azelaic Acid
Glycolic Acid
Arbutin
Peptides
Gluconolactone
Extremozymes
Growth Factors
Ceramides
Centella Asiatica
Iron Oxide
Niacinamide
Kojic Acid
Co-enzyme Q10
Shop by Skin Type
Dark Marks
Dry & Sensitive
Early Ageing, Fine Lines
Mature, Sun Damaged
Normal or Combination
Oily, Acne-Prone
Red, Rosacea-Prone
Shop by Age
Teen
60+
50s
40s
30s
20s
My Account
  • Become a Member
  • Promotions
  • Skin Assessment
  • Video Consultations
  • Learn
  • Dr Ian Webster
  • Contact Us

Introducing Video Consultations

Hyper-personalised one-on-one product advice with a qualified skin therapist.
Book a Session
  • Sign-In
R0.00 0 Cart
Brands

Featured Brands

  • Purcell
  • Melumé Skinscience
  • SkinCeuticals
  • Huxley
  • NeoStrata®
  • Heliocare
  • Beaut™
  • Jorgobé
  • MartiDerm
  • Lamelle
  • Biretix
  • Dermanique
  • iS Clinical
  • Hyaestic
  • PCA Skin
  • pHformula
  • ZO Skin Health
  • Kiehl's
  • mesoestetic
  • Obagi
  • Geske
  • La Roche-Posay
  • CeraVe
  • Colorescience
  • Exuviance
  • Endocare
  • Aveeno
  • Avène
  • Bioderma
  • ISDIN

Shop All

A regenerating anti-ageing serum that reveals a smooth glow!

MARTIDERM NIGHT RENEW SERUM
Skin Type

Skin Type

  • Mature, Sun Damaged
  • Normal or Combination
  • Dark Marks
  • Early Ageing, Fine Lines
  • Dry & Sensitive
  • Oily, Acne-Prone
  • Red, Rosacea-Prone

Shop All

  • Age
Teen
60+
50s
40s
30s
20s

Skin Concern

  • Stretch Marks
  • Eyelash & Eyebrow
  • Actinic Keratosis
  • Adult Acne
  • Post-Acne Marks
  • Expression Lines
  • Perioral Dermatitis
  • Keratosis Pilaris
  • Seborrhoeic Dermatitis
  • Lips
  • Blackheads
  • Atopic Eczema
  • Post-Treatment
  • Pregnancy
  • Psoriasis
  • Redness
  • Scars

Shop All

Huxley’s Conditioning Collection

SHOP NOW
Product Type

Product Type

  • Baby
  • Barrier Creams
  • Cleansers
  • Sunscreens
  • Serums
  • Day Creams
  • Essences
  • Exfoliators
  • Masks
  • Foundation
  • Oral Care
  • Night Creams
  • Starter Kits
  • Micellar Waters
  • Moisturisers
  • Neck Treatments
  • Oils
  • Targeted Treatments
  • Toners
  • Tools & Devices
  • Supplements
  • Foot Treatments
  • Ampoules
  • Eye Care
  • BB & CC Creams
  • Body
  • Men
  • Gift Vouchers
  • Haircare
  • Hand & Nail

Shop All

Designed to mirror the structure of ceramides.

DERMANIQUE
Science

Key Ingredients

  • Cysteamine
  • MicroDiPeptide²²⁹®
  • Polyglutamic Acid
  • Stem Cell Conditioning Media
  • GMOD™ Complex
  • Retinoids
  • Vitamin C
  • Salicylic Acid
  • Growth Factors
  • Alpha-Hydroxy Acids
  • Centella Asiatica
  • Azelaic Acid
  • Glycolic Acid
  • Hyaluronic Acid
  • Melasyl™
  • Polyhydroxy Acid (PHA)
  • Prickly Pear Seed Oil
  • Peptides
  • Co-enzyme Q10
  • Oat Kernel Extract
  • Extremozymes
  • Niacinamide
  • Glutathione
  • Kojic Acid
  • Ceramides
  • Panthenol
  • Iron Oxide
  • Pycnogenol®
  • Gluconolactone
  • NeoGlucosamine

Shop All

Read Dr Webster's Blog

ALL ABOUT UREA
Promotions
Skin Assessment
Learn
Podcast
Dr Ian Webster

Serums

Serums are generally lightweight, but super-efficient and packed with a high percentage active ingredients at optimum concentrations. They are the real workhorses behind any progressive skin care regimen. With smaller molecules they are easily absorbed by skin, and this often leads to more effective and more immediate results. After introducing a serum skin appearance and skin health are often rapidly improved.

Filter

Age
Skin Type
Product Type
Filter Products

Endocare

Endocare Renewal Retinol Intensive Serum

R1,450.00
Rx
Endocare
Endocare Renewal Retinol Intensive Serum
0.5% Retinol Serum Early & Mature Ageing
R1,450.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Blemish + Age Defense Serum

R2,010.00
Rx
SkinCeuticals
SkinCeuticals Blemish + Age Defense Serum

An exfoliating serum that reduces acne-causing bacteria, minimises blotchiness and evens skin tone.

R2,010.00
ADD
VIEW

pHformula

pHformula MD AC Active Recovery

R1,030.00
Rx
pHformula
pHformula MD AC Active Recovery
A treatment serum that helps treat acne and fade post-blemish marks.
R1,030.00
ADD
VIEW

Melumé Skinscience

Melumé Waterfree Niacinamide Galactomyces Serum

R2,550.00
Melumé Skinscience
Melumé Waterfree Niacinamide Galactomyces Serum
A supercharged formula that clarifies pores and reduces sebum for acne-prone skin.
R2,550.00
ADD
VIEW

ZO Skin Health

ZO Skin Health Brightalive 50ml

R3,445.00
ZO Skin Health
ZO Skin Health Brightalive 50ml

A gentle brightening serum that helps fade dark spots and even skin tone.

R3,445.00
ADD
VIEW

iS Clinical

iS Clinical Brightening Complex

R3,720.00
Rx
iS Clinical
iS Clinical Brightening Complex
A brightening moisturiser that helps exfoliate and reduce dark marks and uneven tone.
R3,720.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Discoloration Defense Serum

R2,350.00
Rx
SkinCeuticals
SkinCeuticals Discoloration Defense Serum
A multi-phase, dark spot corrector serum that helps address all forms of hyperpigmentation.
R2,350.00
ADD
VIEW

iS Clinical

iS Clinical Brightening Serum 15ml

R2,030.00
iS Clinical
iS Clinical Brightening Serum 15ml
A brightening serum that helps exfoliate and even out skin tone.
R2,030.00
ADD
VIEW

ISDIN

ISDIN Isdinceutics Retinal Intense

R2,100.00
Rx
ISDIN
ISDIN Isdinceutics Retinal Intense
Rejuvenating Dual Phase Early Ageing Skin
R2,100.00
ADD
VIEW

mesoestetic

mesoestetic aox ferulic

R1,825.00
mesoestetic
mesoestetic aox ferulic
A high-potency antioxidant serum that brightens, firms, and protects.
R1,825.00
ADD
VIEW

Melumé Skinscience

Melumé Power Peptide Micro Emulsion

R3,550.00
Melumé Skinscience
Melumé Power Peptide Micro Emulsion
A daily powerhouse moisturising treatment that firms and lifts for all ageing skin.
R3,550.00
ADD
VIEW

ZO Skin Health

ZO Skin Health Firming Serum

R6,630.00
ZO Skin Health
ZO Skin Health Firming Serum

A firming serum that helps lift, define, and improve skin elasticity and tone.

R6,630.00
VIEW

mesoestetic

mesoestetic skin balance

R2,675.00
mesoestetic
mesoestetic skin balance

A calming serum that soothes and rebalances sensitive, sensitised skin.

R2,675.00
ADD
VIEW

Obagi

Obagi Daily Hydro Drops

R2,315.00
Obagi
Obagi Daily Hydro Drops
Hydrating Illuminating Drops Dry & Dehydrated Skin
R2,315.00
ADD
VIEW

iS Clinical

iS Clinical Retinol+ Emulsion 0.3

R2,570.00
Rx
iS Clinical
iS Clinical Retinol+ Emulsion 0.3
A potent retinol serum that helps smooth, firm, and brighten the skin.
R2,570.00
ADD
VIEW

Kiehl's

Kiehl's Ultra Pure High-Potency 9.8% Glycolic Acid Serum

R880.00
Rx
Kiehl's
Kiehl's Ultra Pure High-Potency 9.8% Glycolic Acid Serum
A refining serum that smooths texture and boosts skin renewal.
R880.00
ADD
VIEW

Obagi

Obagi ELASTIderm® Facial Serum

R4,345.00
Obagi
Obagi ELASTIderm® Facial Serum

Advanced Lifting Serum

Early & Mature Ageing Skin

R4,345.00
ADD
VIEW

ZO Skin Health

ZO Skin Health Brightalive 30ml

R2,220.00
ZO Skin Health
ZO Skin Health Brightalive 30ml
A gentle brightening serum that helps fade dark spots and even skin tone.
R2,220.00
ADD
VIEW

Kiehl's

Kiehl's Clearly Corrective Dark Spot Solution 30ml

R1,250.00
Kiehl's
Kiehl's Clearly Corrective Dark Spot Solution 30ml
Concentrated Brightening Serum Dark Marks & Uneven Tone
R1,250.00
ADD
VIEW

SkinCeuticals

SkinCeuticals H.A. Intensifier Multi-Glycan Serum

R2,250.00
SkinCeuticals
SkinCeuticals H.A. Intensifier Multi-Glycan Serum
A volumising serum designed to help plump and firm for mature ageing skin.
R2,250.00
ADD
VIEW

mesoestetic

mesoestetic skinretin 0.3%

R2,635.00
mesoestetic
mesoestetic skinretin 0.3%

A nighttime retinol treatment that brightens and rejuvenates ageing skin.

R2,635.00
ADD
VIEW

Lamelle

Lamelle RA 3.0

R1,010.00
Rx
Lamelle
Lamelle RA 3.0
An age-preventing retinoid serum that helps support even sensitive skin.
R1,010.00
ADD
VIEW

mesoestetic

mesoestetic age element firming concentrate

R2,515.00
mesoestetic
mesoestetic age element firming concentrate

A anti-ageing serum that firms and restores skin elasticity.

R2,515.00
ADD
VIEW

mesoestetic

mesoestetic melan tran3x concentrate

R2,775.00
mesoestetic
mesoestetic melan tran3x concentrate

An intensive serum targeting stubborn hyperpigmentation and dark marks.

 
R2,775.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Cell Cycle Catalyst

R2,300.00
Rx
SkinCeuticals
SkinCeuticals Cell Cycle Catalyst
This potent multi-acid serum increases cell turnover & smoothes texture for early and mature ageing.
R2,300.00
ADD
VIEW

Bioderma

Bioderma Sebium Serum

R590.00
Bioderma
Bioderma Sebium Serum
A targeted serum for breakouts, dark marks, and early ageing.
R590.00
ADD
VIEW

Lamelle

Lamelle Correctives Brighter Serum

R1,135.00
Lamelle
Lamelle Correctives Brighter Serum
A brightening serum that helps inhibit melanin and boost radiance.
R1,135.00
ADD
VIEW

Exuviance

Exuviance Clarifying and Renewing Serum

R920.00
Exuviance
Exuviance Clarifying and Renewing Serum

A clarifying and rejuvenating serum for oily skin prone to post-acne dark marks.

R920.00
ADD
VIEW

MartiDerm

MartiDerm Absolute Lift Serum

R1,400.00
MartiDerm
MartiDerm Absolute Lift Serum
An advanced firming & lifting serum that helps smooth wrinkles and improve skin elasticity.
R1,400.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Serum 10

R1,550.00
SkinCeuticals
SkinCeuticals Serum 10

A well-tolerated Vitamin C antioxidant serum that is ideal for dry, sensitive or intolerant skin.

R1,550.00
ADD
VIEW

La Roche-Posay

La Roche-Posay Hyalu B5 Serum 30ml

R770.00
La Roche-Posay
La Roche-Posay Hyalu B5 Serum 30ml
Hydrate & Plumping Serum All Skin Types
R770.00
ADD
VIEW

iS Clinical

iS Clinical Youth Serum

R3,895.00
Rx
iS Clinical
iS Clinical Youth Serum
A youth-boosting serum that helps reduce wrinkles and protect against stressors.
R3,895.00
ADD
VIEW
1 2 3 4 5 6 Next
Shop by Top Range
  • SkinCeuticals
  • NeoStrata
  • MartiDerm
  • Huxley
  • Jorgobé
  • Lamelle
  • pHformula
  • Melumé Skinscience
  • Mesoestetic
Customer Experience
  • Help Center
  • Become a Member
  • Video Consultations
  • Newsletter
  • Rx Products
  • DermaPoints Loyalty
  • Terms & Conditions
  • Clinical Studies
  • Gift Vouchers
About Us
  • Contact Us
  • Our Brands
  • Our Story
  • Podcast
  • Google Reviews
  • Distribution

Specialist online skincare store backed by a leading Dermatologist.

Facebook-f Instagram Spotify Apple

© Dermastore® 2025 All Rights Reserved

< Back to all reviews
iS Clinical Youth Serum

Rx

Dermastore® Rx labelled products require registration and a quick once-off multiple choice assessment.

Get Started

Learn more about Rx labelled products.

Already a member?

Login