Growth Factors in Skincare

Growth factors are naturally occurring substances, usually proteins, that are secreted by skin keratinocytes, fibroblasts and platelets. Growth factors affect cell migration, growth, proliferation and differentiation. There are many different types of growth factors which stimulate keratinocytes and fibroblasts to make them function more efficiently. However, these growth factors do not work in isolation and often have to work synergistically with other growth factors.

In recent years, there has been an increased interest in using growth factors as ingredients in skin care products. These growth factors can be derived from various sources including human cells, plants and synthetic production.

Three of the most common growth factors include the following:

Epidermal Growth Factors (EGF)

Clinical studies have been shown to improve the appearance of ageing skin, enhancing skin thickness and reducing wrinkles with regular application. EGF also helps in wound healing.

Fibroblast Growth Factor (FGF)

Stimulates the proliferation of fibroblasts and increases collagen production. Clinical studies have shown that it improves skin elasticity and texture, thereby reduces the appearance of fine lines and wrinkles.

Transforming Growth Factor -Beta (TGF-β)

Play a key role in the synthesis of extracellular matrix components such as collagen and elastin. Clinical studies have shown that it improves skin smoothness and reduces the appearance of wrinkles.

Growth factors are unstable when subjected to high temperatures that can occur during product manufacturing so it is very important to choose products from reputable brands that invest in clinical research and vigorous product testing.

Skincare products containing growth factors

Dr Webster recommends:

• ZO Skin Health Growth Factor Serum
• Endocare Tensage Concentrate (10 units)
• Lamelle Intensive GF Serum
• MartiDerm GF Vital Age Cream (Normal/Combination Skin)