Skip to content
Free delivery on all orders over R750
Click Here
Chat with qualified skin therapists
Click Here
Free samples with every order
Click Here
Explore free gifts & promotions
Click Here
Hello 👋
Shop by Product Type

Shop All

Ampoules
Baby
Barrier Creams
BB & CC Creams
Body
Cleansers
Day Creams
Essences
Exfoliators
Eye Care
Foot Treatments
Foundation
Gift Vouchers
Haircare
Hand & Nail
Masks
Men
Micellar Waters
Moisturisers
Neck Creams
Night Creams
Oils
Oral Care
Serums
Starter Kits
Sunscreens
Supplements
Targeted Treatments
Toners
Tools & Devices
Shop by Brand

Shop All

Melumé Skinscience
SkinCeuticals
Dr. Barbara Sturm
Huxley
NeoStrata®
Heliocare
Beaut™
Jorgobé
MartiDerm
Lamelle
iS Clinical
Hyaestic
PCA Skin
pHformula
ZO Skin Health
Kiehl's
mesoestetic
Obagi
La Roche-Posay
CeraVe
Exuviance
FEEV
Shop by Concern
Actinic Keratosis
Adult Acne
Atopic Eczema
Blackheads
Expression Lines
Eyelash & Eyebrow
Keratosis Pilaris
Lips
Perioral Dermatitis
Post-Acne Marks
Post-Treatment
Pregnancy
Psoriasis
Redness
Scars
Seborrhoeic Dermatitis
Stretch Marks
Shop by Science

Shop All

Retinoids
Vitamin C
Hyaluronic Acid
Azelaic Acid
Glycolic Acid
Arbutin
Peptides
Gluconolactone
Extremozymes
Growth Factors
Ceramides
Centella Asiatica
Iron Oxide
Niacinamide
Kojic Acid
Co-enzyme Q10
Shop by Skin Type
Dark Marks
Dry & Sensitive
Early Ageing, Fine Lines
Mature, Sun Damaged
Normal or Combination
Oily, Acne-Prone
Red, Rosacea-Prone
Shop by Age
Teen
60+
50s
40s
30s
20s
My Account
  • Become a Member
  • Promotions
  • Skin Assessment
  • Video Consultations
  • Learn
  • Dr Ian Webster
  • Contact Us

Introducing Video Consultations

Hyper-personalised one-on-one product advice with a qualified skin therapist.
Book a Session
  • Sign-In
R0.00 0 Cart
Brands

Featured Brands

  • Biretix
  • Melumé Skinscience
  • SkinCeuticals
  • Dr. Barbara Sturm
  • Huxley
  • NeoStrata®
  • Heliocare
  • Beaut™
  • Jorgobé
  • MartiDerm
  • Lamelle
  • Dermanique
  • iS Clinical
  • Hyaestic
  • PCA Skin
  • pHformula
  • ZO Skin Health
  • Kiehl's
  • mesoestetic
  • Obagi
  • Geske
  • La Roche-Posay
  • CeraVe
  • Colorescience
  • Exuviance
  • Endocare
  • Aveeno
  • Avène
  • Bioderma
  • ISDIN

Shop All

Triple action invisible photo protection.

PHFORMULA PRO DEFENCE³
Skin Type

Skin Type

  • Mature, Sun Damaged
  • Normal or Combination
  • Dark Marks
  • Early Ageing, Fine Lines
  • Dry & Sensitive
  • Oily, Acne-Prone
  • Red, Rosacea-Prone

Shop All

  • Age
Teen
60+
50s
40s
30s
20s

Skin Concern

  • Stretch Marks
  • Eyelash & Eyebrow
  • Actinic Keratosis
  • Adult Acne
  • Post-Acne Marks
  • Expression Lines
  • Perioral Dermatitis
  • Keratosis Pilaris
  • Seborrhoeic Dermatitis
  • Lips
  • Blackheads
  • Atopic Eczema
  • Post-Treatment
  • Pregnancy
  • Psoriasis
  • Redness
  • Scars

Shop All

Promoting hair strength, volume & a gorgeous glossy look.

HUXLEY
Product Type

Product Type

  • Baby
  • Barrier Creams
  • Cleansers
  • Sunscreens
  • Serums
  • Day Creams
  • Essences
  • Exfoliators
  • Masks
  • Foundation
  • Oral Care
  • Night Creams
  • Starter Kits
  • Micellar Waters
  • Moisturisers
  • Neck Creams
  • Oils
  • Targeted Treatments
  • Toners
  • Tools & Devices
  • Supplements
  • Foot Treatments
  • Ampoules
  • Eye Care
  • BB & CC Creams
  • Body
  • Men
  • Gift Vouchers
  • Haircare
  • Hand & Nail

Shop All

Designed to mirror the structure of ceramides.

DERMANIQUE
Science

Key Ingredients

  • GMOD™ Complex
  • Retinoids
  • Vitamin C
  • Salicylic Acid
  • Growth Factors
  • Alpha-Hydroxy Acids
  • Centella Asiatica
  • Azelaic Acid
  • Glycolic Acid
  • Hyaluronic Acid
  • Melasyl™
  • Polyhydroxy Acid (PHA)
  • Prickly Pear Seed Oil
  • Peptides
  • Co-enzyme Q10
  • Oat Kernel Extract
  • Extremozymes
  • Niacinamide
  • Glutathione
  • Kojic Acid
  • Ceramides
  • Panthenol
  • Iron Oxide
  • Pycnogenol®
  • Gluconolactone
  • NeoGlucosamine
  • Arbutin
  • Copper Tripeptides
  • Avocado
  • Sodium PCA

Shop All

Arbutin helps to treat all forms hyperpigmentation.

READ THE BLOG
Promotions
Skin Assessment
Learn
Podcast
Dr Ian Webster
skinceuticals-discoloration-defense-1400px.webp
skinceuticals-discoloration-defense-open-1400px.jpg
skinceuticals-discoloration-defense-1400px.webp
skinceuticals-discoloration-defense-open-1400px.jpg

Rx

Targeted Treatments / SkinCeuticals

SkinCeuticals Discoloration Defense Serum

★★★★★ 5.00/5

R2,350.00

Earn 1176 DermaPoints

A multi-phase, dark spot corrector serum that helps address all forms of hyperpigmentation.

SOLD OUT
ADD TO CART
Description

SkinCeuticals Discoloration Defense is a new-generation, multi-phase dark spot corrector serum that helps address melasma and post-inflammatory hyperpigmentation (PIH). Suitable for hyperpigmentation and uneven skin tone.

Key ingredients include Tranexamic Acid, a synthetically derived ingredient that assists in inhibiting the release of inflammatory mediators, specifically prostaglandins and arachidonic acid, which are involved in melanogenesis. Studies have also demonstrated its ability to address hard-to-treat forms of hyperpigmentation, including post-acne marks. Niacinamide, also known as vitamin B3, offers proven skin-brightening benefits. HEPES is a synthetically derived acid that activates natural enzymes in the skin to help break the bonds that bind dead skin cells to the surface for even exfoliation. Fragrance-free. Hydroquinone-free.

Dr. Webster’s Recommendation: SkinCeuticals Discoloration Defense is a layerable, daily-use serum that targets dark marks, helping to brighten the skin without aggravating it. Ideal for use post-hydroquinone treatment, or as a standalone home care routine with the inclusion of a SkinCeuticals antioxidant serum and retinoid. Always use a high-factor, broad-spectrum sunscreen to protect and prevent the skin against UV-induced hyperpigmentation.

Summary

Strength: 1.8% Tranexamic Acid, 5% Niacinamide, 5% HEPES

Size: 30ml

SPF: None

Fragrance-Free: Yes

Application: Face

Use: AM/PM

How to Use
  • Apply 3-5 drops of Discoloration Defense twice a day after cleansing in the morning and evening.
  • If using a SkinCeuticals antioxidant: CE Ferulic or Phloretin CF in the morning, apply this first and once absorbed apply the Discoloration Defense.
  • If using in the morning, apply after a SkinCeuticals antioxidant and follow with a SkinCeuticals broad-spectrum sunscreen.
  • Limit sun exposure while using this product & always use a good quality, high factor, broad spectrum sunscreen every day - compliancy is vital when treating pigmentation.
  • Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Key Ingredients
  • Niacinamide
  • Tranexamic Acid
  • HEPES

FULL INGREDIENTS / INCI: AQUA/WATER, BUTYLENE GLYCOL, NIACINAMIDE, HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID, GLYCERIN, HYDROXYETHYL UREA, PROPYLENE GLYCOL, TRANEXAMIC ACID, PHENOXYETHANOL, CAPRYLYL GLYCOL, ALLANTOIN, CHLORPHENESIN, XANTHAN GUM, DISODIUM EDTA, D227872/1 CN: 190767.7 ACL: 6116075 CNP: 6253393
Works Well With

SkinCeuticals

SkinCeuticals Physical Fusion UV Defense SPF 50

R1,050.00
SkinCeuticals
SkinCeuticals Physical Fusion UV Defense SPF 50
An advanced, lightweight, 100% mineral sunscreen offering broad-spectrum protection.
R1,050.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Metacell Renewal B3

R2,550.00
SkinCeuticals
SkinCeuticals Metacell Renewal B3
A multi-corrective moisturiser that targets early ageing, dullness, discolouration, and dryness.
R2,550.00
ADD
VIEW

SkinCeuticals

SkinCeuticals Gentle Cleanser Cream

R850.00
SkinCeuticals
SkinCeuticals Gentle Cleanser Cream
Soothing Creamy Cleanser Sensitive & Dry Skin
R850.00
ADD
VIEW

Customer Reviews

5

/5

Based on 03 rating(s)

5 Star
100%
3 review(s)
4 Star
0%
0 review(s)
3 Star
0%
0 review(s)
2 Star
0%
0 review(s)
1 Star
0%
0 review(s)

Reviewed by 03 customer(s)

Sort by

  • Sandy

    Excellent product. Will highly recommend it to ladies battling with hyperpigmentation and dark spots. I use it with the Phoretin CF followed by Discoloration Defense and then Metacell.

    September 15, 2024
    Verified Review

    Helpful?

    Reply
  • Chantal

    Amazing products. I started using this product about two months ago in conjunction with (Skinceuticals Phloretin CF & Metacell Renewal B3) and have seen an amazing result in the lightening of the pigmentation on my face. After battling with pigmentation for the past 10 years and trying just about every treatment and product on the market I can honestly say I have found the perfect product for me. Thank you for the excellent advise. Will definitely continue using this serum.

    December 18, 2019
    Verified Review

    Helpful?

    Reply
  • Farida

    I’ve used this serum (in conjunction with the Advanced Pigment Corrector) just over a month and I can already see results. My skin feels smooth and much brighter. Pigmentation and brown marks are starting to fade. A remarkable improvement. Thank you for the excellent advice and recommendation.

    September 18, 2018
    Verified Review

    Helpful?

    Reply

Leave feedback about this Cancel reply

You must be logged in to post a review.

Video

Dr Webster also recommends

mesoestetic

mesoestetic melan tran3x concentrate

R2,775.00
mesoestetic
mesoestetic melan tran3x concentrate
Intensive Pigment Correcting Serum Dark Marks & Hyperpigmentation
R2,775.00
ADD
VIEW

pHformula

pHformula MD TXN Serum

R1,395.00
Rx
pHformula
pHformula MD TXN Serum
Concentrated Serum Dark Marks & Uneven Skin
R1,395.00
ADD
VIEW

MartiDerm

MartiDerm DSP Bright Ampoules (30 units)

R1,400.00
Rx
MartiDerm
MartiDerm DSP Bright Ampoules (30 units)
60-Day Brightening Program Hyperpigmentation
R1,400.00
ADD
VIEW
Shop by Top Range
  • SkinCeuticals
  • NeoStrata
  • MartiDerm
  • Huxley
  • Lamelle
  • pHformula
  • Melumé
  • ZO Skin Health
Customer Experience
  • Help Center
  • Become a Member
  • Video Consultations
  • Newsletter
  • Rx Products
  • DermaPoints Loyalty
  • Terms & Conditions
  • Clinical Studies
  • Gift Vouchers
About Us
  • Contact Us
  • Our Brands
  • Our Story
  • Podcast
  • Google Reviews
  • Distribution

Specialist online skincare store backed by a leading Dermatologist.

Facebook-f Instagram Spotify Apple

© Dermastore® 2025 All Rights Reserved

Rx

Dermastore® Rx labelled products require registration and a quick once-off multiple choice assessment.

Get Started

Learn more about Rx labelled products.

Already a member?

Login